Description
Afatinib 40 mg Tablets – First-Line Targeted Therapy for EGFR+ Lung Cancer
Afatinib 40 mg is an oral anti-cancer medication used in the treatment of non-small cell lung cancer (NSCLC) with specific epidermal growth factor receptor (EGFR) mutations. It belongs to a class of drugs called tyrosine kinase inhibitors (TKIs) and is often prescribed as a first-line treatment in patients whose tumors carry EGFR exon 19 deletions or exon 21 (L858R) mutations.
Key Features & Benefits:
- Standard starting dose for most adult patients with EGFR+ NSCLC
- Blocks EGFR and related kinases to stop tumor cell proliferation
- Improves progression-free survival in advanced lung cancer
- Convenient once-daily oral dosing
- Used in precision medicine based on genetic profiling
How to Use:
Take Afatinib 40 mg once daily on an empty stomach (at least 1 hour before or 2 hours after food). Swallow the tablet whole with water. Do not chew, split, or crush the tablet. Continue therapy unless your doctor advises otherwise or until unacceptable side effects occur.
Precautions:
- Not recommended during pregnancy or breastfeeding
- Regular monitoring of liver function, lungs, and skin is advised
- Inform your doctor of all current medications and health conditions
- Diarrhea and skin reactions are common and should be managed promptly
Storage:
Store in a cool, dry place between 15°C and 30°C. Protect from light and moisture. Keep out of reach of children.
Frequently Asked Questions (FAQs)
1. What is Afatinib 40 mg used for?
Afatinib 40 mg is prescribed for treating metastatic non-small cell lung cancer in patients with confirmed EGFR mutations such as exon 19 deletions or exon 21 substitutions.
2. Is Afatinib 40 mg the starting dose for everyone?
Yes, 40 mg is the usual starting dose for most adults. However, dose reductions to 30 mg or 20 mg may be necessary if side effects become intolerable.
3. How long can Afatinib be taken?
Afatinib can be taken for months or even years, depending on how well your cancer responds and your ability to tolerate the drug. Treatment continues until disease progression or severe side effects occur.
4. What are the common side effects?
Diarrhea, rash, mouth sores, nail changes, and fatigue are common. Severe or persistent side effects should be reported to your doctor immediately.
5. Can Afatinib be taken with other cancer drugs?
Afatinib is generally used as monotherapy for EGFR-positive lung cancer. However, your oncologist may consider combining it with other treatments based on disease progression or mutations.
6. Is it safe to use Afatinib during pregnancy?
No. Afatinib may harm a developing fetus. Women of childbearing age should use effective contraception during treatment and consult their doctor.
7. Can I drink alcohol while taking Afatinib?
Alcohol may increase side effects or interfere with your liver function. Always consult your doctor before drinking alcohol during cancer therapy.
