Description
Regorafenib 40 mg Tablets – Targeted Therapy for Advanced Cancer
Regorafenib 40 mg is an oral targeted therapy used in the treatment of certain advanced cancers including metastatic colorectal cancer (mCRC), gastrointestinal stromal tumors (GIST), and hepatocellular carcinoma (HCC). It works by inhibiting multiple protein kinases involved in tumor growth, angiogenesis (blood vessel formation), and cancer cell survival.
Key Benefits:
- Approved for use in advanced colorectal, liver, and gastrointestinal cancers
- Oral tablet – convenient administration
- Delays disease progression and extends survival in eligible patients
- Multi-kinase inhibitor targeting tumor growth and blood supply
- Generic alternative to Stivarga® – affordable and accessible
How to Use:
Take as directed by your oncologist, typically 160 mg once daily (4 x 40 mg tablets) for 21 days followed by 7 days off, in a 28-day cycle. Swallow whole with water after a low-fat meal. Do not crush or split the tablets.
Indications:
- Metastatic colorectal cancer (mCRC) after failure of prior treatments
- Gastrointestinal stromal tumors (GIST) resistant to imatinib and sunitinib
- Unresectable hepatocellular carcinoma (HCC) after sorafenib
Precautions & Side Effects:
- Common side effects: fatigue, hand-foot skin reaction, diarrhea, hypertension, weight loss
- Regular monitoring of liver function and blood pressure is required
- Not recommended during pregnancy or breastfeeding
- Use with caution in patients with liver impairment
- May interact with other cancer drugs – inform your doctor of all medications
Storage Instructions:
Store at room temperature (below 25°C) in the original blister pack. Keep away from moisture and light. Keep out of reach of children.
Frequently Asked Questions (FAQs)
1. What is Regorafenib used for?
It is used to treat metastatic colorectal cancer, gastrointestinal stromal tumors, and advanced liver cancer after failure of other treatments.
2. How should Regorafenib 40 mg be taken?
Typically, 160 mg daily (4 tablets) for 21 days, followed by 7 days off. Always follow the exact schedule given by your oncologist.
3. Can Regorafenib 40 mg cure cancer?
No. It is not a cure, but it may slow progression, relieve symptoms, and extend life in patients with specific cancers.
4. What are the most common side effects of Regorafenib 40 mg?
Fatigue, high blood pressure, mouth sores, hand-foot syndrome, and gastrointestinal issues like diarrhea are common. Regular monitoring is essential.
5. Is Regorafenib chemotherapy?
No. Regorafenib is a targeted therapy (kinase inhibitor), not traditional cytotoxic chemotherapy. It specifically blocks cancer cell growth pathways.
6. How long can you stay on Regorafenib?
As long as the drug is effective and tolerable. Treatment duration is based on individual response and side effect management by the oncologist.
