Description
Tolvaptan 30 mg Tablets – Treatment for ADPKD & Hyponatremia
Tolvaptan 30 mg is a selective vasopressin V2-receptor antagonist used to manage autosomal dominant polycystic kidney disease (ADPKD) and correct hyponatremia (low blood sodium) caused by the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH). Tolvaptan helps slow the progression of kidney damage in ADPKD patients and restores sodium balance in fluid-overloaded conditions.
Key Features & Benefits:
- Slows cyst growth and kidney function decline in ADPKD
- Increases serum sodium by promoting free water clearance
- Effective in managing SIADH-induced hyponatremia
- Oral therapy taken once or twice daily as prescribed
- Monitored for liver safety and sodium balance
Indications:
- Adults with rapidly progressing ADPKD
- Patients with clinically significant hyponatremia from SIADH
How to Use:
Take this medication exactly as prescribed by your doctor. Usually taken once or twice daily with or without food. Do not exceed prescribed fluid intake unless instructed. Do not split or crush tablets.
Important Warnings:
- Requires routine liver function tests (LFTs) due to risk of hepatotoxicity
- Discontinue immediately if signs of liver injury occur
- Do not consume grapefruit juice while using this medication
Common Side Effects:
- Thirst, dry mouth
- Frequent urination (polyuria), nocturia
- Fatigue, dizziness
- Elevated liver enzymes (ALT/AST)
Storage:
Store below 30°C in a dry place away from light and moisture. Keep out of reach of children and pets.
Frequently Asked Questions (FAQs)
1. What is Tolvaptan 30 mg used for?
It is used to treat ADPKD by slowing the growth of kidney cysts and preserving kidney function. It is also used to treat low blood sodium caused by SIADH.
2. Is Tolvaptan a cure for ADPKD?
No, it is not a cure. However, it helps slow the disease progression and preserves kidney function for a longer time.
3. Why is liver monitoring necessary?
Tolvaptan has been associated with liver toxicity. Regular liver function tests are required to detect problems early and prevent serious complications.
4. Can I drink water normally while on Tolvaptan 30 mg?
You may need to limit water or fluid intake. Your doctor will guide you based on your sodium levels and kidney condition.
5. Are there interactions with other medicines?
Yes. Avoid strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin) and grapefruit juice. Inform your doctor about all medications you’re taking.
6. How quickly does Tolvaptan 30 mg work?
For hyponatremia, it may begin correcting sodium within 8–24 hours. For ADPKD, long-term use is required to see kidney protection benefits.
