Description
Tolvaptan 15 mg Tablets – Treatment for Hyponatremia & ADPKD
Tolvaptan 15 mg is a vasopressin V2-receptor antagonist used to treat clinically significant hyponatremia (low blood sodium) associated with SIADH (Syndrome of Inappropriate Antidiuretic Hormone Secretion), and to slow the progression of ADPKD (Autosomal Dominant Polycystic Kidney Disease). It works by helping the body eliminate excess water while retaining sodium, thereby correcting fluid imbalance.
Key Benefits:
- Increases serum sodium levels in hyponatremia
- Delays renal function decline in ADPKD patients
- Oral tablet for convenient administration
- Selective action on vasopressin V2 receptors in the kidneys
- Reduces need for IV fluid restriction in hospitalized patients
How to Use:
Take exactly as prescribed by your healthcare provider. Usually taken once daily, with or without food. Avoid drinking excessive fluids unless directed.
Who Can Use:
- Adults diagnosed with ADPKD or SIADH-induced hyponatremia
- Not suitable for: patients with anuria, liver impairment, or those unable to sense or respond to thirst
- Requires liver monitoring and regular blood sodium level checks
Possible Side Effects:
- Common: thirst, dry mouth, increased urination, polyuria
- Less common: fatigue, dizziness, increased liver enzymes
- Serious: liver injury, dehydration, hypernatremia
Warnings:
- Do not use if you are unable to access water or if you are volume-depleted
- Monitor liver function tests before and during treatment
- Avoid grapefruit juice while taking Tolvaptan
Storage Instructions:
Store at room temperature (15–30°C), away from heat and moisture. Keep out of reach of children.
Frequently Asked Questions (FAQs)
1. What is Tolvaptan used for?
Tolvaptan is used to treat low blood sodium (hyponatremia) due to SIADH and to slow the progression of autosomal dominant polycystic kidney disease (ADPKD).
2. How does Tolvaptan work?
It blocks vasopressin V2 receptors in the kidneys, promoting water excretion without losing sodium, which corrects fluid balance.
3. Can Tolvaptan cure ADPKD?
No. It does not cure ADPKD but slows the progression of kidney enlargement and preserves kidney function over time.
4. Is liver monitoring necessary?
Yes. Tolvaptan can cause liver damage. Liver function tests must be done before and during treatment.
5. Can I drink water normally while on Tolvaptan?
No. You may need to limit fluid intake to avoid overhydration. Follow your doctor’s instructions carefully regarding fluid balance.
6. Are there any drug interactions?
Yes. Avoid CYP3A inhibitors (like ketoconazole) and grapefruit juice, as they may increase Tolvaptan levels and toxicity risk.
